Involvement of the cholinergic mechanism in depression of the caudate spindle
Open Access
- 1 January 1979
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 29 (3) , 399-403
- https://doi.org/10.1254/jjp.29.399
Abstract
Involvement of the cholinergic and catecholaminergic mechanisms in the caudate spindle recorded from the anterior and posterior sigmoid gyri was studied in cats. Physostigmine (0.01-0.1 mg/kg i.v.) abolished the appearance of the caudate spindle. The inhibitory effects were antagonized by the administration of atropine (0.25-1 mg/kg i.v.). The caudate spindle was inhibited by high frequency stimulation of the mesencephalic reticular formation. This effect was antagonized by atropine; L-dopa (25-50 mg/kg i.v.), L-dopa + MAO [monoamine oxidase] inhibitor and methamphetamine (0.5-5 mg/kg i.v.) did not influence the caudate spindle. Apparently a cholinergic mechanism is involved in caudate spindle depression.This publication has 6 references indexed in Scilit:
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