X-ray crystallographic proof of electrophilic attack at the pyrimidine/imidazole ring junction in guanosine
- 1 January 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 3 (6) , 641-645
- https://doi.org/10.1093/carcin/3.6.641
Abstract
The crystal structure of a novel nucleoside isolated from guanosine/p-methylbenzyl chloride reactions demonstrates linkage between the methylene carbon of the benzyl moiety and carbon-5 of guanosine, and loss of the carbonyl function at carbon-6 of guanosine, to yield 4-(p-methylbenzyl)-5-guanidino-1-.beta.-D-ribofuranosylimidazole. Carbon-5 of guanine in DNA is evidently a potential site of reaction for electrophilic ultimate carcinogens.This publication has 6 references indexed in Scilit:
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