A problem associated with the measurement of ketone body kinetics in vivo
- 1 November 1981
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 59 (11) , 1178-1180
- https://doi.org/10.1139/y81-181
Abstract
[3–14C]acetoacetate (AcAc) and [2–14C]acetate were infused in separate experiments into nine paired rats. The specific activity (SA) ratio SAβOHB/SAAcAc was 0.23 ± 0.02 when [3–14C]AcAc was the tracer and 0.78 ± 0.1 when [2–14C]acetate was infused. These experiments demonstrate the inadequacy of the common practice of using only one labelled ketone body to calculate the turnover rate of both AcAc and β-hydroxybutyrate (βOHB) simultaneously.This publication has 3 references indexed in Scilit:
- Kinetics of ketone body metabolism in fasting humansMetabolism, 1979
- Ketone body turnover and net hepatic ketone production in fasted and diabetic dogs.American Journal of Physiology-Endocrinology and Metabolism, 1978
- Enzymic determination of d(−)-β-hydroxybutyric acid and acetoacetic acid in bloodBiochemical Journal, 1962