Skeletal Magnesium Changes in the Rat during Varying Dietary Fluoride Intake and Growth

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Abstract
Previous work has shown that elevated intakes of fluoride by mature animals result in an augmentation of the skeletal magnesium concentration. This work describes the effects on skeletal magnesium content when 3 levels of supplemental fluoride were supplied to weanling rats over increasing time-periods. Albino rats were maintained from weanling age with fluoride intakes of either zero, 50, or 100 ppm in the drinking water for periods of 4, 8, 12, and 24 weeks. The analyses for magnesium and fluoride in the humeri indicated that the magnesium content in bone ash decreased with age whereas the total magnesium content of the bone increased. These results indicate that less magnesium was incorporated into the bone mineral resulting in an apparent dilution of magnesium as maturation of the bone occurs. The effect of fluoride at the levels used was to limit the dilution of the magnesium in bone.

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