Baseline Topographic Optic Disc Measurements Are Associated With the Development of Primary Open-Angle Glaucoma

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Abstract
Numerous studies have assessed the ability of confocal scanning laser ophthalmoscopy (CSLO) optic disc measurements to discriminate between healthy eyes and eyes with established glaucoma in cross-sectional studies. Estimates of sensitivity and specificity range from 58% to 88% and 73% to 96%, respectively.1-8 Few studies have evaluated CSLO optic disc topography in ocular hypertensive eyes without glaucomatous-appearing optic discs or visual field damage.9 The Ocular Hypertension Treatment Study (OHTS), with its large cohort of participants with ocular hypertension without clinically evident optic disc or visual field damage at study entry, provides a unique opportunity to detect changes in the optic disc prior to the determination of primary open-angle glaucoma (POAG) by OHTS criteria. One of the primary aims of the CSLO Ancillary Study to the OHTS was to describe the association of baseline CSLO optic disc topographic measurements and indexes with the development of POAG among participants enrolled in this ancillary study.10,11 To our knowledge, this is the first report to evaluate whether CSLO topographic optic disc measurements are associated with the development of glaucomatous optic disc or visual field damage in patients with ocular hypertension.

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