The influence of calcium and magnesium on manganese transport and utilization in Mice

Publisher Website
Google Scholar
Abstract
The influence of high but not extreme concentrations of Ca and Mg in water (25 µmol/mL) and of similar concentrations in food (25 µmol/g) on the absorption and retention of54Mn in mice was investigated. Addition of either Ca or Mg reduced the absorption of54Mn from water (administered by intragastric intubation) and from food (a portion made available for consumption during 1.5 h) by more than 50%. The retention of intraperitoneally injected54Mn was not influenced by addition of Ca or Mg (25 µmol/mL) to the drinking water. In mice fed a Ca-depleted diet during 2 wk prior to dosage, the absorption of54Mn from an intubated aqueous solution was increased by more than 100% compared to that in mice fed a Ca-adequate diet. In mice fed a Mg-depleted diet or a Ca- or Mg-replete diet for 2 wk, no changes in the absorption of54Mn were observed. In mice fed a Ca,Mg-depleted diet after54Mn administration, the turnover of absorbed54Mn was strongly increased, probably as a result of increased absorption of stable Mn from the diet. The results indicate that the uptake of Mn could be higher in soft water regions than in hard water regions.