Inorganic phosphate accumulation and cadmium detoxification in Klebsiella aerogenes NCTC 418 growing in continuous culture

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Abstract
K. aerogenes NCTC 418, growing in the presence of Cd under glucose-, sulfate- or phosphate-limited conditions in continuous culture, exhibits 2 different Cd detoxifying mechanisms. In addition to sulfide formation, increased accumulation of Pi is demonstrated as a novel mechanism. Intracellular Cd is always quantitatively counterbalanced by a concerted increase in both inorganic sulfide and Pi contents of the cells. Thus, production of sulfide and accumulation of Pi are detoxification mechanisms present in K. aerogenes but their relative importance is crucially dependent on the strain and the growth conditions employed.