Cytomegalovirus infection and schizencephaly: Case reports
- 1 January 1998
- journal article
- case report
- Published by Wiley in Annals of Neurology
- Vol. 43 (1) , 123-127
- https://doi.org/10.1002/ana.410430122
Abstract
Two children with left open‐lip schizencephaly are reported. Cytomegalovirus (CMV) infection was demonstrated on the second day of life in Patient 1; in the other patient CMV infection was observed at the age of 4 years. Magnetic resonance imaging revealed polymicrogyric cortex lining the clefts. In Patient 2 polymicrogyria was also present in the corresponding area contralateral to the schizencephaly. Computed tomography revealed the presence of subependymal periventricular calcifications. Genetic analysis did not demonstrate the presence of EMX2 homeobox gene. The possible role of CMV infection in the complex multifactorial pathogenesis of schizencephaly is therefore suggested.Keywords
This publication has 10 references indexed in Scilit:
- Familial schizencephaly associated with EMX2 mutationNeurology, 1997
- Heterosexual behavior during pregnancy and perinatal transmission of HIV-1AIDS, 1996
- X-linked malformations of neuronal migrationNeurology, 1996
- Germline mutations in the homeobox gene EMX2 in patients with severe schizencephalyNature Genetics, 1996
- Ganciclovir therapy for symptomatic congenital cytomegalovirus infection in infants: A two-regimen experienceThe Journal of Pediatrics, 1994
- Detection of a nonsense mutation in the dystrophin gene by multiple SSCPHuman Molecular Genetics, 1992
- Lethal cytomegalovirus infection in preterm infants: Clinical, radiological, and neuropathological findingsAnnals of Neurology, 1992
- Severe outcome of brain perfusion failure: A pre-hydranencephalic state?Brain & Development, 1991
- Lissencephaly-Pachygyria Associated With Congenital Cytomegalovirus InfectionJournal of Child Neurology, 1991
- Prenatal Cytomegalovirus Disease and Cerebral Microgyria: Evidence for Perfusion Failure, not Disturbance of Histogenesis, as the Major Cause of Fetal Cytomegalovirus EncephalopathyNeuropediatrics, 1984