Growth of the cartilages of the mid-line cranial base of the Wistar rat: an autoradiographic study using 35S-sulphate
- 1 February 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in European Journal of Orthodontics
- Vol. 13 (1) , 75-80
- https://doi.org/10.1093/ejo/13.1.75
Abstract
Matrix synthesis in the mid-line cranial base of the rat was studied using a single injection of 35S-sulphate in animals aged 4–80 days. High uptake of 36S-sulphate in the morphologically distinct zone of early hypertrophy led to it being renamed the Matrixogenic Zone. Relocation of 35S-sulphate label into the primary spongiosa was used to estimate the growth rate of each site of endochondral ossification. This showed a marked caudorostral and temporal gradient. In addition, there was a caudorostral and temporal gradient in hypertrophic cell size, but only a temporal gradient in the rate of cell loss.Keywords
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