PATHOLOGIC PHYSIOLOGY OF LEAD COLIC

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Abstract
The clinical studies of James Mackenzie and of Arthur Hertz have led us to the conclusion that intestinal cramps and colics occur when a wave of peristalsis passes down on a segment of intestine which is already in a state of tonic or spastic constriction. Such zones of spastic constriction are very often present, obliterating the lumen of the intestine and causing a stasis of intestinal contents above them. If this rule holds, it is most likely true also for the condition which gives rise to the colic in lead poisoning, and perhaps also that which causes the gastric crises of tabes dorsalis and of angina abdominis; and it would be natural to expect that any drug which relieves these conditions would also produce inhibition of intestinal peristalsis and spasm. As early as 1874, Riegel and Frank noted that lead colic was associated with increased hardness of the pulse and

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