Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors
Top Cited Papers
- 23 February 2007
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 315 (5815) , 1133-1137
- https://doi.org/10.1126/science.1136610
Abstract
Smell is an ancient sensory system present in organisms from bacteria to humans. In the nematode Caeonorhabditis elegans , gustatory and olfactory neurons regulate aging and longevity. Using the fruit fly, Drosophila melanogaster , we showed that exposure to nutrient-derived odorants can modulate life span and partially reverse the longevity-extending effects of dietary restriction. Furthermore, mutation of odorant receptor Or83b resulted in severe olfactory defects, altered adult metabolism, enhanced stress resistance, and extended life span. Our findings indicate that olfaction affects adult physiology and aging in Drosophila , possibly through the perceived availability of nutritional resources, and that olfactory regulation of life span is evolutionarily conserved.Keywords
This publication has 22 references indexed in Scilit:
- Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In VivoPLoS Biology, 2006
- Behavioral, physical, and demographic changes in Drosophila populations through dietary restrictionAging Cell, 2005
- Compensatory ingestion upon dietary restriction in Drosophila melanogasterNature Methods, 2005
- Insect chemoreceptionCurrent Opinion in Neurobiology, 2005
- Calories Do Not Explain Extension of Life Span by Dietary Restriction in DrosophilaPLoS Biology, 2005
- The Molecular Basis of Odor Coding in the Drosophila LarvaNeuron, 2005
- Or83b Encodes a Broadly Expressed Odorant Receptor Essential for Drosophila OlfactionNeuron, 2004
- The Molecular Basis of Odor Coding in the Drosophila AntennaPublished by Elsevier ,2004
- Demography of Dietary Restriction and Death in DrosophilaScience, 2003
- Does overexpression of Cu,Zn-SOD extend life span in Drosophila melanogaster?Experimental Gerontology, 2003