HYPERACUTE RENAL ALLOGRAFT REJECTION IN THE RABBIT

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Abstract
SUMMARY The pathogenesis of hyperacute rejection of renal allografts was investigated in randomly bred rabbits sensitized by ear skin allografts. Four of six kidneys from the skin donor and 3 of 4 kidneys from unrelated nonspecific rabbits transplanted in sensitized recipients developed diffuse cortical necrosis. Serum from 10 other skin-sensitized rabbits was injected into the left renal artery of the skin donor (specific) and into the left renal artery of previously unused rabbits (nonspecific). Diffuse cortical necrosis developed in 3 of 10 specific skin donors whose kidneys were injected with serum from skin-sensitized rabbits. Of 10 nonspecific rabbits, kidneys injected with serum from sensitized rabbits, 2 developed cortical necrosis. Heparin treatment at a dose of 2 mg/kg of skin-sensitized renal allograft recipients did not entirely prevent the development of diffuse cortical necrosis. None of the sensitized recipients treated with heparin in a dose of 10 or 20 mg/kg manifested cortical necrosis (P<0.01). Four of six recipients treated with papaverine developed cortical necrosis, and one had diffuse tubular necrosis, indicating the inefficacy of this treatment approach.

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