A Mouse Model of Acute Bacterial Rhinosinusitis

Abstract
THE MOST basic definition of rhinosinusitis is inflammation of the lining membrane of any of the paranasal sinuses. This definition, however, has limited pathologic and clinical significance. Rhinosinusitis has manifestations ranging from an incidental computed tomographic scan finding1,2to an acute illness after an upper respiratory tract viral infection3 to an unremitting illness associated with a genetic abnormality in the epithelium of patients with cystic fibrosis.4