Microtubule Contribution to the Reflectance of the Retinal Nerve Fiber Layer
- 1 December 2006
- journal article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 47 (12) , 5363-5367
- https://doi.org/10.1167/iovs.06-0451
Abstract
Purpose. The reflectance of the retinal nerve fiber layer (RNFL) arises from light scattering by cylindrical structures oriented parallel to ganglion cell axons. In amphibian retinas, at 440 nm, microtubules (MTs) contribute about one half of RNFL reflectance. In rodent retinas, MTs are the only structure contributing to RNFL birefringence. To increase understanding of the anatomic basis for clinical RNFL measurements, this study was conducted to evaluate the MT contribution to RNFL reflectance in rodent retinas by using the MT depolymerizing agent colchicine.Keywords
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