Successful GnRH Treatment in a Patient with Kallmann's Syndrome, who previously failed HMG/HCG Treatment/Erfolgreiche GnRH-Behandlung bei einem Mann mit Kallmann-Syndrom bei vorher erfolgloser HMG-HCG-Behandlung

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Abstract
A successful GnRH treatment for hypogonadotropic hypogonadism is described. A 40 year old infertile patient due to Kallmann''s syndrome, associated with obesity and NIDDM, was treated with HCG (5,000 IU/week) for 8 years. In an attempt to induce spermatogenesis HMG (75 IU/daily) was added for 2 years. During the combined gonadotropin treatment semen analysis indicated an improvement from azoospermia to 2 .times. 106 sperm/ml. Since semen quality remained poor and obviously no pregnancy was achieved, the last regime was replaced by a pulsatile GnRH treatment (5 mcg/90 minutes). Following 6 months sperm count increased up to 15 .times. 106 associated with normal motility and morphology. Patient''s wife conceived after the second intrauterine insemination and delivered a full term healthy baby.