Tissue nucleic acids

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Abstract
The nucleic acid and nucleotide conc. was examined in a series of rat livers from fed and fasting animals, in the pregnant and embryo rat, in the regenerating rat liver and in liver tumors induced by feeding butter yellow. The total nucleic acid conc. as measured by the nucleoprotein P, rose on fasting, was high in pregnancy, and very high in the embryo. It was not appreciably altered in the regenerating liver, and was slightly raised in liver tumors. The acid soluble nucleotide conc. was unaltered on fasting, was raised in regenerating livers, was low in liver tumors, and very low in embryo livers. Of the total nucleic acid a large proportion (70-90%) was present as ribonucleic acid. On fasting, the ribonucleic acid conc. fell by about 12%, while the desoxyribonucleic acid conc. rose, both changes being statistically significant. The ratio of ribonucleic acid P to desoxyribonucleic acid P therefore fell on fasting, was the same in regenerating as in control livers, and was lower in liver tumors and in embryo livers than in the normal liver, although in both liver tumor and in the embryo, particularly the latter, the concs. of both ribonucleic acid and desoxyribonucleic acid were higher than in normal liver.

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