MELANOMA

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Abstract
Melanoma, melanosarcoma, or melanocarcinoma is a malignant tumor growth composed of pigmented cells. Ewing1inclines to the view that tumors of this type arise from a specific mesoblastic cell, the chromatophore, and possibly also from cells of the epithelial type which have been modified by pigment production. He writes: "Theoretical considerations favor the origin of all melanomas from the mesoblastic chromatophore, while the histology favors their origin from epithelial cells which have taken on pigmentary function. The established tumors exhibit carcinomatous or sarcomatous structures, or both." The melanomas are usually primary in the skin as pigmented moles of congenital origin. They may remain quiescent for a long period, or they may become rather early malignant in character. They are also found primary in the choroid of the eye, the iris, the pigmented areas adjacent to the conjunctiva, the pia mater, the arachnoid, the rectum and, less frequently, in other

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