Abstract
Several papules on the floor of the mouth and the ventral surface of the tongue of a Zn-deficient rabbit were studied by light microscopy and EM. These papules were consistent with focal epithelial hyperplasia of man and chimpanzee. There was a concurrence of cytoplasmic vacuolization with the appearance of viral particles within the nucleus. Intranuclear crystalline viral aggregates were frequently observed in the upper spinous cells.

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