SOLID PHASE SYNTHESIS AND SOME PHARMACOLOGICAL PROPERTIES OF 8‐D‐HOMOARGININE‐VASOPRESSIN AND 1‐DEAMINO‐8‐D‐HOMOARGININE‐VASOPRESSIN
- 1 March 1976
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 8 (2) , 193-198
- https://doi.org/10.1111/j.1399-3011.1976.tb02495.x
Abstract
Fully protected 8-D-lysine-vasopressin and 1-deamino-8-D-lysine-vasopressin were synthesized by the solid phase method. Selective removal of the lysine protection and reaction with 1-guanyl-3,5-dimethylpyrazole converted D-lysine into D-homoarginine. The title compounds were then obtained by treatment with sodium in liquid ammonia and oxidation in dilute aqueous solution. Although the antidiuretic activities are lower than for the corresponding D-arginine derivatives, the even lower pressor effects make the new analogues highly specific antidiuretic agents. The A/P ratios for 8-D-homo-arginine-vasopressin and its 1-deamino derivative are 100 and 3,300, respectively.This publication has 23 references indexed in Scilit:
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