Enteric-coated acetylsalicylic acid plus dipyridamole compared with anticoagulants in the prevention of ischemic events in patients with transient ischemic attacks

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Abstract
Patients (88) entered on open non-random study carried out on hospitalized patients with a history of transient ischemic attacks or amaurosis fugax. Ninety-two patients received peroral anticoagulants usually combined with heparin treatment during the 1st days of treatment, and 96 patients enteric-coated acetylsalicylic acid 0.5 g twice daily plus dipyridamole 75 mg twice daily. The patients were followed up, irrespective of whether treatment was changed or not. Recurrent transient ischemic attack or amaurosis fugax occurred more frequently (P < 0.01) from 2 mo. of follow-up and throughout the observation period in the antiplatelet-treated group. There were no statistically significant differences between the 2 grups on the originally given treatment for endpoints such as stroke (6 patients on anticoagulants, 12 patients on antiplatelet therapy) or stroke or death (11 patients on anticoagulants, 17 patients on antiplatelet therapy). Anticoagulant treatment apparently is superior to antiplatelet therapy given in the prevention of ischemic attacks and this difference mainly exists during the first one to 2 mo. after onset of transient ischemic attacks or amaurosis fugax.