Inhibition of macrophage migration by muramyl peptides
- 1 May 1979
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 24 (2) , 308-312
- https://doi.org/10.1128/iai.24.2.308-312.1979
Abstract
In the capillary tube migration system a synthetic muramyl dipeptide (MDP; N-acetylmuramyl-L-alanyl-D-isoglutamine), a part of bacterial cell wall peptidoglycans, inhibited the migration of peritoneal exudate macrophages from normal guinea pigs or rats. The migration inhibition was also caused by some MDP-containing peptidoglycan fragments from cell walls of Lactobacillus plantarum and Staphylococcus epidermidis. The migration inhibition could not be explained on the basis of macrophage migration inhibitory factor. A stereochemically highly specific structure of MDP required for its adjuvant activity was also required for the macrophage migration inhibition. These findings suggest that MDP and MDP-containing cell wall fragments may activate macrophages and that this activation may be important in the exertion of their adjuvant activity.This publication has 18 references indexed in Scilit:
- Inhibition of macrophage migration by synthetic muramyl dipeptideBiochemical and Biophysical Research Communications, 1978
- Nonspecific activation of murine spleen cells in vitro by a synthetic immunoadjuvant (N-acetyl-muramyl-l-alanyl-d-isoglutamine)Cellular Immunology, 1977
- Correlation of stereochemically specific structure in muramyl dipeptide between macrophage activation and adjuvant activityBiochemical and Biophysical Research Communications, 1977
- Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs.Proceedings of the National Academy of Sciences, 1977
- Functional activation of immune lymphocytes by antigenic stimulation in cell-mediated immunity II. Analysis of the macrophage-replacing activity of the LPS-stimulated macrophage culture supernatant in the antigenic activation of purified immune lymphocytesCellular Immunology, 1976
- Correlation of structure and adjuvant activity of N-acetyl muramyl-L-alanyl-D-isoglutamine (MDP), its derivatives and analogues. Anti-adjuvant and competition properties of stereoisomersBiochemical and Biophysical Research Communications, 1976
- Functional activation of immune lymphocytes by antigenic stimulation in cell mediated immunity: I. Requirement for macrophages in antigen-induced MIF production by guinea pig immune lymphocytes in vitroCellular Immunology, 1975
- Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell linesJournal of Clinical Investigation, 1972
- The determination of the molecular size of peptides and proteins by chromatography on Bio Gel P-100 columns in phenol-acetic acid-water (1:1:1, w/v/v) solvent mixtureBiochimica et Biophysica Acta (BBA) - Protein Structure, 1970
- Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.Proceedings of the National Academy of Sciences, 1966