Solid tumor models for assessment of different treatment modalities: therapeutic strategy for sequential chemotherapy with radiotherapy.

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Abstract
A therapeutic strategy for combined radiotherapy and chemotherapy of experimental solid tumors was devised. More effective utilization of combined chemotherapy and radiotherapy may be realized clinically if comparable information is obtained in man. The overall treatment efficiency of successive courses of treatment was determined by a method that defines tumor response quantitatively over an entire spectrum of tumor responses. The findings of this study showed that an individual tumor that responds well to the 1st course of therapy will respond well to the 2nd and 3rd courses of combined modality therapy. Various solid tumors in different animal species demonstrated variability of response to treatment, analogous to the many types of response found clinically.