Interleukin-5 mRNA in Mucosal Bronchial Biopsies from Asthmatic Subjects
Open Access
- 1 January 1991
- journal article
- intercellular messengers
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 94 (1-4) , 169-170
- https://doi.org/10.1159/000235353
Abstract
Using in situ hybridization, we have investigated the expression of interleukin-5 (IL-5) mRNA in bronchial biopsies from asthmatics (n = 10) and controls (n = 9). The number of IL-5-mRNA-positive cells were compared with the number of CD25+ and EG2+ cells and total eosinophil counts. Specific hybridization signals for IL-5 mRNA were demonstrated in 6 out of the 10 asthmatic subjects but in none of the controls. The 6 IL-5-mRNA-positive asthmatics tended to have more severe disease and showed a significant increase in the degree of infiltration of the bronchial mucosa by activated T lymphocytes and eosinophils.Keywords
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