Electrophilic cyclization reaction of gem-difluoroolefin derivatives: Syntheses of 6,6-difluorotetrahydro-2-pyrones and 2,2-difluorotetrahydropyran via halogen induced cyclization.

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Abstract
The halocyclization reactions of gem-difluoroolefin derivatives (4, 5 and 8) with iodine in acetonitrile proceed in the 6-endo mode selectively providing 6, 6-difluorotetrahydro-2-pyrones (9) and 2, 2-difluorotetrahydropyran (10), respectively.