A QUANTITATIVE STUDY OF CELL PROLIFERATION IN EPENDYMA AND CHOROID PLEXUS IN THE POSTNATAL RAT BRAIN

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Abstract
Proliferative activity in forebrain ependyma and choroid plexus epithelium was studied in rats aged up to 42 days by autoradiography after injection of [3H]-thymidine. Labeling indices were higher in the lateral than in the 3rd ventricle, while values for choroid plexus epithelium were lower than those for ependyma. In all areas examined, labeling indices showed a similar pattern of decline in the first 2 postnatal weeks reaching by day 12 a level about 20-30% of that on day 1. This low level, corresponding to a turnover time of 130 days for ependyma, was maintained thereafter up to day 42, indicating the persistence of proliferation in the young adult.