Agonist-receptor efficacy I: mechanisms of efficacy and receptor promiscuity

This publication has 12 references indexed in Scilit:

• Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.
  Published by Elsevier ,2021
• A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.
  Published by Elsevier ,2021
• Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
  Published by Elsevier ,2002
• Membrane organization in G‐protein mechanisms
  The FASEB Journal, 1994
• Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
  Nature, 1993
• Immunoprecipitation of alpha 2a-adrenergic receptor-GTP-binding protein complexes using GTP-binding protein selective antisera. Changes in receptor/GTP-binding protein interaction following agonist binding.
  Journal of Biological Chemistry, 1992
• Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits.
  Journal of Biological Chemistry, 1992
• Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation
  Cell, 1991
• Specific activation of G_s by synthetic peptides corresponding to an intracellular loop of the β‐adrenergic receptor
  FEBS Letters, 1991
• On the application of “a plausible model” of allosteric proteins to the receptor for acetylcholine
  Journal of Theoretical Biology, 1967