Immune Function and Cytochrome P4501A Activity after Acute Exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) in Channel Catfish
- 1 September 1995
- journal article
- Published by Oxford University Press (OUP) in Journal of Aquatic Animal Health
- Vol. 7 (3) , 195-204
- https://doi.org/10.1577/1548-8667(1995)007<0195:ifacpa>2.3.co;2
Abstract
Several commercial polychlorinated biphenyl (PCB) mixtures reduce immune functions in fish. However, little is known about the effects of specific coplanar PCBs on immune functions in fish. We investigated the effects of a single, acute exposure to either corn oil as a carrier control or 0.01, 0.1, and 1.0 mg/kg body weight of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on both nonspecific cellular immune responses and antigen-specific humoral immune responses in channel catfish Ictalurus punctatus. Fish were given PCB 126 intraperitoneally, and innate cellular immune responses were evaluated 3 and 7 d later. The humoral immune response against Edwardsiella ictaluri was evaluated 14 d after treatments. Immunological results were compared to cytochrome P4501A induction, ethoxyresorufin O-deethylase (EROD) activity, allometric indices, and hematology as biomarkers of exposure and effects 3 and 7 d posttreatment. Cytochrome P4501A and EROD activity were induced by all three doses of PCB 126, whereas a...Keywords
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