The Relationship between QTc Changes and Nutrition during Weight Loss after Gastroplasty

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Abstract
ECG, serum electrolytes, plasma concentrations of pre-albumin and retinol-binding globulin and dietary intakes were analyzed in 22 women during weight loss after gastroplasty surgery for morbid obesity. QT interval corrected for heart rate (QTc) was prolonged (> 0.44 s) in 32% (95% confidence limits 14-55%) on 1 or more occasions. No clinical or ECG complications were seen. Occurrence of QTc prolongation was significantly (P < 0.05) associated with protein intake below recommendation and with low plasma pre-albumin concentrations. QTc prolongation was not associated with mineral intake and occurred in spite of normal serum levels of C (uncorrected and albumin-corrected), Mg, K and Na. Because QTc prolongation may precede fatal arrhythmias, adequate protein intake is mandatory during weight reduction.