Studies on the mode of action of vitamin K

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Abstract
Active prothrombin is precipitated from the plasma of normal chicks by the acetone method of Howell and the acetic acid method of Mellanby; the corresponding precipitate from the plasma of K-avitaminous chicks is inactive as prothrombin. The prothrombin precipitate from normal chicken plasma is still active after removal of lipids by acetone and ether, and the lipids obtained in this way and those extracted from the plasma itself by alcohol and ether have no prothrombin activity. A concentrate of vitamin K did not accelerate clotting in vitro, when tested against plasma + thrombokinase.

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