Evidence for a persistent central depressant action seen after recovery from anaesthesia

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Abstract
The fate of the classical adrenaline reversal in anaesthetised and in conscious cats was investigated. It seems that anaesthesia has some late effects on pharmacological responses that can be demonstrated for up to 72 hr after recovery of consciousness. The adrenaline reversal typical of the anaesthetised cat persisted for up to 72 hr after recovery of consciousness, thereafter the response to intravenous adrenaline was entirely pressor.