1HNMR studies on human plasma lipids from newborn infants, healthy adults, and adults with tumors
- 1 January 1989
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 9 (1) , 35-38
- https://doi.org/10.1002/mrm.1910090106
Abstract
The 1HNMR spectra of the lipid region of human plasma from healthy adults, neonates, and patients with malignant and nonmalignant tumors have been recorded on a JNM‐GX400 FT spectrometer operating at 399.6 MHz for protons. The chemical shifts of methylene and methyl groups of plasma lipids were measured with respect to the higher field component of the methyl proton resonance of the lactate molecule. The results show that there are changes in the chemical shifts of the methylene proton resonances among the plasma from healthy adults, adults with tumors, and neonates. The shifts observed in the case of cancer patients and neonates are in the direction opposite to the shift measured from the plasma of healthy adults. Thus, the observed changes cannot be explained by the activity in the cell proliferation of tissues which is high in the cases of both healthy neonates and patients with malignant tumors, but they most probably reflect the different lipoprotein compositions of neonates, healthy adults, and adults with tumors. © 1989 Academic Press, Inc.This publication has 11 references indexed in Scilit:
- Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the USAThe American Journal of Clinical Nutrition, 1987
- Detection of Malignant TumorsNew England Journal of Medicine, 1986
- Plasma lipids and prolactin in patients with breast cancerBritish Journal of Cancer, 1986
- A proteolipid in cancer cells is the origin of their high‐resolution NMR spectrumFEBS Letters, 1986
- Influence of dietary factors on the plasma lipoprotein composition and content in neonatesEuropean Journal of Pediatrics, 1986
- NMR Analysis of Cancer CellsPublished by Springer Nature ,1986
- Lipid domain in cancer cell plasma membrane shown by 1H NMR to be similar to a lipoproteinFEBS Letters, 1985
- Isolation and characterization of an RNA-proteolipid complex associated with the malignant state in humans.Proceedings of the National Academy of Sciences, 1985
- The composition and concentration of umbilical cord plasma lipoproteins; their relationship to the birth weight and other clinical factors of the newbornClinica Chimica Acta; International Journal of Clinical Chemistry, 1983
- Peculiarities of hyperlipidaemia in tumour patientsBritish Journal of Cancer, 1981