Cholestyramine: Use as a New Therapeutic Approach for Chlordecone (Kepone) Poisoning
- 24 February 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4331) , 893-895
- https://doi.org/10.1126/science.74852
Abstract
In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method for treating chronic poisoning with this and possibly with other lipophilic toxins.This publication has 3 references indexed in Scilit:
- Analysis of Chlordecone [Kepone®] in Biological Specimens*Journal of Analytical Toxicology, 1977
- The Interaction Between Cholestyramine and DrugsExperimental Biology and Medicine, 1965