The influence of hexobarbitone on calcium ion movements in isolated heart muscle

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Abstract
In beating atria (frequency 180/min) sodium hexobarbitone (7·8 × 10−4M) inhibited the rate of uptake of 45Ca2+ from the medium without influencing the total calcium content of the tissues. Concomitantly, the so-called exchangeable calcium fraction was diminished although not at equilbrium. In resting left auricles the barbiturate did not affect 45Ca+-uptake or the exchangeable calcium fraction. It seems likely that the barbiturate reduces membrane permeability towards Ca2+ during excitation without influencing the permeability at rest.

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