Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease
- 1 September 1997
- journal article
- case report
- Published by Springer Nature in Bone Marrow Transplantation
- Vol. 20 (6) , 511-515
- https://doi.org/10.1038/sj.bmt.1700912
Abstract
We report three patients with lethal forms of acute GVHD in whom all biopsy specimens showed a striking preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha. The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the existence of primary macrophagic forms of GVHD is discussed.Keywords
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