CSF immune com plexes in multiple sclerosis
- 1 March 1985
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 35 (3) , 429
- https://doi.org/10.1212/wnl.35.3.429
Abstract
Immune complexes from the CSF of 12 individuals (6 with exacerbations of MS and 6 with other neurologic or psychiatric disease) were isolated and characterized. Three MS patients had complexed herpes simplex type I viral antigen and antibody; three patients had complexed myelin basic protein. Two MS patients and one with hypoxic encephalopa-thy had complexed antibody directed against brain glycolipids. CSF complexes were distinct from serum complexes, suggesting intrathecal origin. Reactivation of latent brain virus may play a role in exacerbations of MS.Keywords
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