Feasibility of an HA2 Domain-Based Periodontitis Vaccine
Open Access
- 1 January 2003
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (1) , 562-566
- https://doi.org/10.1128/iai.71.1.562-566.2003
Abstract
In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.Keywords
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