Total Synthesis of (±)-Kelsoene
- 1 January 2001
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2001 (14) , 2138-2142
- https://doi.org/10.1055/s-2001-18063
Abstract
(±)-Kelsoene (1) has been synthesized in 15 steps from commercially available cyclopent-2-en-1-one. Key steps include (a) a methylenecyclopentane annulation of cyclopent-2-en-1-one using the bifunctional cuprate reagent lithium cyano(4-chlorobut-1-en-2-yl)cuprate and (b) a highly stereoselective [2+2]-photocycloaddition of ethylene to the bicyclic enone 10.Keywords
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