Computerized analysis of sleep recordings applied to drug evaluation: Midazolam in normal subjects
- 1 April 1981
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 29 (4) , 533-541
- https://doi.org/10.1038/clpt.1981.75
Abstract
Computerized analysis of polygraphic sleep recordings was carried out for the evaluation of midazolam, a benzodiazepine hypnotic. The analysis was carried out in real time on a small laboratory computer and the output included the hypnogram and relative power profiles for the main EEG activities. Analysis showed a slight intranight rapid eye movement rebound during medication and reduction of sleep stage 4 after withdrawal. The relative power of the delta frequency band did not change during medication or withdrawal.This publication has 0 references indexed in Scilit: