Fettlösliche Vitamine und Atherosklerose

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Abstract
Old atherosclerotic hens were given large oral doses of vitamin K1, A and E for periods between 75 and 100 days. The individual aortas were examined macroscopically, the fats extracted and the total lipides from the liver and serum isolated. Free and esterified cholesterol and phos-phatides were determined separately in all total fat fractions. Vitamin K1 was found to have no effect on atherosclerosis in the case of old hens or of young cockerels fed with cholesterol. A slight antiathero-sclerotic effect was observed with vitamin E in a few cases with very large doses. With vitamin A on the other hand macroscopic examination showed a marked regression of the atheromatosis in all the tests groups, this being accompanied by reduction of the total fat content of the aorta. The combined administration of vitamin A and E was found to be the most effective and produced a very considerable diminution of the fat plaques and of the total fat and cholesterol content of the aorta. The A and E groups and in some cases the A groups, showed a striking shift in the composition of the cholesterol fractions in the liver in favor of the cholesterol esters. Lipide analysis of the serum obtained at the conclusion of the experiments showed no characteristic differences.

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