A SYNTHESIS OF PHENYLALANINE AND TYROSINE

Publisher Website
Google Scholar
Abstract
Acrylonitrile and diazonium chlorides are condensed to give α-chloro-β-arylpropionitriles which can be converted to α-amino acids. Phenylalanine is obtained by transforming α-chloro-β-phenylpropionitrile into the amide with sulphuric acid, hydrolysing to the acid with hydrochloric acid and animating with ammonia and ammonium carbonate. Tyrosine is obtained from α-chloro-β-p-methoxyphenylpropionitrile by direct hydrolysis with mixed acetic and hydrochloric acids and ammonolysis with ammonia and ammonium carbonate.

This publication has 0 references indexed in Scilit: