Temperature Dependence of Electron Capture Detector Responses in the Analysis of Chlorpromazine, Diazepam, and Clonazepam
- 1 January 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 3 (1) , 18-20
- https://doi.org/10.1093/jat/3.1.18
Abstract
The temperature dependence of the responses of a pulsed 63 Ni electron capture detector to chlorpromazine, clomipramine, diazepam, flurazepam, and the N-ethyl derivatives of clonazepam and N-desmethylflunitrazepam were determined. The response to chlorpromazine and clomlpramine increases with temperature, while that to diazepam and flurazepom decreases with temperature. The response to N-ethylclonazepam and N-ethyldesmethylflunitrazepam exhibits very little temperature dependence. These results have been used to optimize the analysis of chlorpromazine, diazepam, and clonazepam in plasma by electron capture gas-liquid chromatography.This publication has 2 references indexed in Scilit:
- Rapid gas chromatographic method for the determination of clonazepam in serum and cerebrospinal fluidJournal of Chromatography A, 1976
- Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma by using gas-liquid chromatography with an electron capture detectorAnalytical Chemistry, 1968