Alterations in O2 uptake following hemorrhage in dogs

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Abstract
In paralyzed mechanically ventilated dogs, when acid-base balance was maintained within 0.1 pH unit of 7.40, blood loss amounting to 25 ml/kg was followed by significant increase in O2 uptake (VO2) P< 0.05) which persisted for 90 min. following retransfusion. This increase in VO2 was not observed in a similar preparation when moderate hypercapnic acidosis (pH 7.20, PaCO2 52 mm Hg) was produced following hemorrhage or when the animals were pretreated with butoxamine and pH was maintained normal. It is postulated that the increase in VO2 that occurs after moderate hemorrhage could be due to the stimulation of the sympathoadrenal system and catecholamine release which would produce an accelerated turnover of free fatty acids. This calorigenic effect of the catechola-mines would not be observed in the presence of acidosis or after treatment with butoxamine which are known to inhibit the metabolic effects of the catecholamines.

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