Distribution of H-2 Alloantigenic Specificities on Radiolabeled Papain-Solubilized Antigen Fragments
Open Access
- 1 August 1971
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 107 (2) , 563-570
- https://doi.org/10.4049/jimmunol.107.2.563
Abstract
A method for determining the distribution of H-2 alloantigenic specificities on papain-solubilized fragments has been developed. Partially purified, radiolabeled antigen was reacted with monospecific alloantiserum and the antigen-antibody complex was removed by gel filtration or disc gel electrophoresis. Several specificities were shown to reside on the same fragment because monospecific sera removed specificities in addition to the one against which each serum was directed.Keywords
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