EFFECTS OF SULPHINPYRAZONE AND ASPIRIN ON PROSTAGLANDIN I2 (PROSTACYCLIN) SYNTHESIS BY ENDOTHELIAL CELLS
Open Access
- 1 December 1978
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 64 (4) , 481-483
- https://doi.org/10.1111/j.1476-5381.1978.tb17308.x
Abstract
Synthesis of prostaglandin I2, (PGI2, prostacyclin) by vascular endothelium (assayed by the ability of cultured endothelial cells to inhibit platelet aggregation) was inhibited by aspirin. At 100 μmol/1 aspirin completely blocked measurable PGI2 production, but endothelial cells had substantially recovered their ability to synthesize PGI2 24 h after removal of the drug. In contrast, the effect of 1 mmol/1 aspirin was still evident 24 h after drug withdrawal. Sulphinpyrazone also inhibited PGI2 synthesis, but was about 100 fold less potent than aspirin, and the effect of the drug was lost within 24 h of its addition, even when endothelial cells were left in contact with the drug during this period.Keywords
This publication has 17 references indexed in Scilit:
- DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLINThe Lancet, 1978
- Sulfinpyrazone in the Prevention of Cardiac Death after Myocardial InfarctionNew England Journal of Medicine, 1978
- Localisation and stimulation of prostacyclin production in vascular cellsNature, 1978
- Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endotheliumThrombosis Research, 1977
- Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandinBiochemical and Biophysical Research Communications, 1977
- HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATIONThe Lancet, 1977
- An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregationNature, 1976
- A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial InfarctionBMJ, 1974
- Duration of inhibition of platelet prostaglandin formation and aggregation by ingested aspirin or indomethacinProstaglandins, 1973
- Aggregation of Blood Platelets by Adenosine Diphosphate and its ReversalNature, 1962