Probable Metabolic Interaction Between Methadone and Fluvoxamine in Addict Patients

1 February 1994

journal article
research article
Published by Wolters Kluwer Health in Therapeutic Drug Monitoring

Vol. 16 (1) , 42-45
https://doi.org/10.1097/00007691-199402000-00006

Abstract

Summary We report five cases where fluvoxamine (FLVX) was added to maintenance treatment with methadone (MTD) in addict patients with affective disorders. In view of the implication of FLVX in several metabolic drug interactions, MTD plasma levels were measured before and after treatment with FLVX. A slight increase (∼20% of the MTD plasma level/dose ratio) occurred in two cases. In the remaining three patients, the interaction was more pronounced (40–100% increase of the MTD plasma level/dose ratio), with clinical manifestations of opiate withdrawal after stopping FLVX therapy in one case. Caution is needed when starting or stopping treatment with FLVX in patients receiving maintenance treatment with methadone.

Keywords

This publication has 0 references indexed in Scilit: