Intravesical Instillation of Oxybutynin Hydrochloride for Detrusor Hyper‐reflexia

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Abstract
Summary The effect of intravesical oxybutynin hydrochloride on detrusor behaviour was studied in 15 patients with urinary incontinence due to detrusor hyper‐reflexia by ambulatory bladder monitoring. Twelve patients had a reduction in the frequency and amplitude of hyper‐reflexic contractions and incontinence episodes following oxybutynin administration. Intravesical oxybutynin may have a role in the management of patients on intermittent self‐catheterisation with detrusor hyper‐reflexia who cannot tolerate the side effects of anticholinergic agents, including oxybutynin.