Soluble interleukin-2 receptor in Sezary syndrome: its origin and clinical application

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Abstract
Soluble interIeukin-2 receptor (sIL-2R) serum levels were evaluated in Sézary syndrome (SS). mycosis fungoides. non-epidermotropic T-cell lymphomas. inflammatory skin diseases (eczema, psoriasis and lichen planus) and benign erythroderma. All groups displayed mean values significantly higher than controls, and values in SS were also significantly higher than those in the other diseases investigated. Follow-up of 17 SS patients showed that serum SIL-2R correlated with the clinical course of the disease and with other haematologicai parameters (ahsolute numher of circulating Sézary cells, lactic dehydrogenase). Culture experiments demonstrated that, in contrast with other haematoiogical disorders, highly enriched resting Sézary cells were unahle to release sII-2R. and failed to release normal amounts even after mitogen stimulation. Nevertheless, the leukaemic burden, together with the activation and consequent CD25 expression of leukaemic lymphocytes infiltrating the skin, may justify the hypothesis of a neoplastie sIL-2R source. To further support this hypothesis, the highest sIT.-2R values were found in patients with advanced disease, in which normal reactive lymphocytes were dramatically reduced.

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