(E,E)-10-(1,3-Dihydro-4,6-dihydroxy-7-methyl-3-oxoisobenzofuran-5-yl)4,8-dimethyldeca-4,8-dienoic acid: total synthesis and role in mycophenolic acid biosynthesis

Abstract
The title compound (2), a prenylogue of mycophenolic acid (4), has been synthesized by two different routes; experiments show unambiguously that (2) is a biosynthetic intermediate of mycophenolic acid.

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