An Improved Procedure for the Synthesis of Bicyclo[2.2.2]octane-2,6-dione
- 1 June 1993
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 23 (11) , 1499-1505
- https://doi.org/10.1080/00397919308011243
Abstract
Conjugate addition of Meldrum's acid to 2-cyclohexenone followed by direct cyclization in PPA/acetic acid constitutes a shorter, more reproducible and higher yielding route to bicyclo[2.2.2]octane-2,6-dione than previous methods. The crude dione could be used as substrate for the baker's yeast reduction to (1R, 4S, 6S)-bicyclo[2.2.2]octane-6-ol-2-one.Keywords
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