Correlation of isomeric fatty acids in human adipose tissue with clinical risk factors for cardiovascular disease

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Abstract
The relationships between the adipose tissue concentrations of 19 geometric and positional fatty acid isomers and 10 cardiovascular disease risk factors were determined in 76 free-living adult males. The percentages for trans isomers (total x̄ ± SD 4.14 ± 0.97%) and cis isomers (total x̄ ± SD 2.91 ± 0.34%) in adipose tissue generally agreed with dietary estimates based on the consumption of hydrogenated oils. A major exception was the percentage of 11c-18:1, which was twofold higher in adipose tissue. The total level of fatty acid isomers in adipose tissue or a factor (derived by factor analysis) that was representative of isomers of dietary origin was not significantly correlated with the cardiovascular risk factors. Only three trans isomers (11t-8:1, 12t-8:1, and 5t-4:1) and three cis isomers (11c-18: 1, 13c-18:1, and 7c-16:1) were weakly correlated either positively or negatively with age, body mass index, plasma and lipoprotein cholesterol, and/or blood pressure (P < 0.05, r > 0.231).